The latest study from the Jill Roberts Institute, "β2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses," was published on March 2 in Science. To read more, click here.  Dr. Gregory Sonnenberg wins inaugural award from the Society for Mucosal Immunology. To read more, click here.  The Kenneth Rainin Foundation awarded Dr. Iliyan Iliev and colleagues from Mount Sinai a $250,000 Synergy Award to examine the composition of the fungal community in babies born to mothers with inflammatory bowel disease. To read more, click here. Dr. Randy Longman received the Irma T. Hirschl Career Scientist Award and the New York Crohn’s Foundation Award.    

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The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

TitleThe soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.
Publication TypeJournal Article
Year of Publication2016
AuthorsChorny, A, Casas-Recasens, S, Sintes, J, Shan, M, Polentarutti, N, García-Escudero, R, A Walland, C, Yeiser, JR, Cassis, L, Carrillo, J, Puga, I, Cunha, C, Bastos, H, Rodrigues, F, Lacerda, JF, Morais, A, Dieguez-Gonzalez, R, Heeger, PS, Salvatori, G, Carvalho, A, Garcia-Sastre, A, J Blander, M, Mantovani, A, Garlanda, C, Cerutti, A
JournalJ Exp Med
Date Published2016 Sep 19

Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 to splenic marginal zone (MZ) B cells, an innate-like subset of antibody-producing lymphocytes strategically positioned at the interface between the circulation and the adaptive immune system. PTX3 was released by a subset of neutrophils that surrounded the splenic MZ and expressed an immune activation-related gene signature distinct from that of circulating neutrophils. Binding of PTX3 promoted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular polysaccharides, which decreased in PTX3-deficient mice and humans. In addition, PTX3 increased IgM and IgG production after infection with blood-borne encapsulated bacteria or immunization with bacterial carbohydrates. This immunogenic effect stemmed from the activation of MZ B cells through a neutrophil-regulated pathway that elicited class switching and plasmablast expansion via a combination of T cell-independent and T cell-dependent signals. Thus, PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for MZ B cells. This property could be harnessed to develop more effective vaccines against encapsulated pathogens.

Alternate JournalJ. Exp. Med.
PubMed ID27621420
PubMed Central IDPMC5030794
Grant ListP01 AI061093 / AI / NIAID NIH HHS / United States
R01 AI057653 / AI / NIAID NIH HHS / United States
U01 AI095613 / AI / NIAID NIH HHS / United States