In Situ Support of ILC Precursors.

TitleIn Situ Support of ILC Precursors.
Publication TypeJournal Article
Year of Publication2020
AuthorsZhou, L, Sonnenberg, GF
JournalImmunity
Volume52
Issue2
Pagination207-209
Date Published2020 Feb 18
ISSN1097-4180
Abstract

Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that promote immunity to pathogens at mucosal barriers, but the mechanisms regulating their development within tissues remain poorly understood. In this issue of Immunity, Oherle et al. identify a niche in the neonatal airway where stromal cell-derived insulin-like growth factor 1 (IGF1) supports the proliferation of ILC precursors and protects from infection.

DOI10.1016/j.immuni.2020.01.011
Alternate JournalImmunity
PubMed ID32075721