Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer.

TitleMicrobiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer.
Publication TypeJournal Article
Year of Publication2022
AuthorsRuiz, DFZegarra, Kim, DV, Norwood, K, Saldana-Morales, FB, Kim, M, Ng, C, Callaghan, R, Uddin, M, Chang, L-C, Longman, RS, Diehl, GE
JournalGut Microbes
Volume14
Issue1
Pagination2119054
Date Published2022 Jan-Dec
ISSN1949-0984
KeywordsAnimals, Colitis, Colitis-Associated Neoplasms, Disease Models, Animal, Escherichia coli, Gastrointestinal Microbiome, Humans, Inflammation, Inflammatory Bowel Diseases, Interleukin-10, Macrophages, Microbiota
Abstract

Inflammatory bowel disease (IBD) is a chronic life-long inflammatory disease affecting almost 2 million Americans. Although new biologic therapies have been developed, the standard medical treatment fails to selectively control the dysregulated immune pathways involved in chronic colonic inflammation. Further, IBD patients with uncontrolled colonic inflammation are at a higher risk for developing colorectal cancer (CRC). Intestinal microbes can impact many immune functions, and here we asked if they could be used to improve intestinal inflammation. By utilizing an intestinal adherent E. coli that we find increases IL-10 producing macrophages, we were able to limit intestinal inflammation and restrict tumor formation. Macrophage IL-10 along with IL-10 signaling to the intestinal epithelium were required for protection in both inflammation and tumor development. Our work highlights that administration of immune modulating microbes can improve intestinal outcomes by altering tissue inflammation.

DOI10.1080/19490976.2022.2119054
Alternate JournalGut Microbes
PubMed ID36062329
PubMed Central IDPMC9450902
Grant ListP30 CA008748 / CA / NCI NIH HHS / United States
P30 CA125123 / CA / NCI NIH HHS / United States
P30 AI036211 / AI / NIAID NIH HHS / United States
S10 RR024574 / RR / NCRR NIH HHS / United States
R01 AI125264 / AI / NIAID NIH HHS / United States