Metabolic regulation of innate and adaptive lymphocyte effector responses.

TitleMetabolic regulation of innate and adaptive lymphocyte effector responses.
Publication TypeJournal Article
Year of Publication2018
AuthorsJoseph, AM, Monticelli, LA, Sonnenberg, GF
JournalImmunol Rev
Volume286
Issue1
Pagination137-147
Date Published2018 Nov
ISSN1600-065X
Abstract

Innate and adaptive lymphocytes employ diverse effector programs that provide optimal immunity to pathogens and orchestrate tissue homeostasis, or conversely can become dysregulated to drive progression of chronic inflammatory diseases. Emerging evidence suggests that CD4 T helper cell subsets and their innate counterparts, the innate lymphoid cell family, accomplish these complex biological roles by selectively programming their cellular metabolism in order to instruct distinct modules of lymphocyte differentiation, proliferation, and cytokine production. Further, these metabolic pathways are significantly influenced by tissue microenvironments and disease states. Here, we summarize our current knowledge on how cell-intrinsic metabolic factors modulate the context-dependent bioenergetic pathways that govern innate and adaptive lymphocytes. Further, we propose that a greater understanding of these pathways may lead to the identification of unique features in each population and provoke the development of novel therapeutic strategies to modulate lymphocytes in health and disease.

DOI10.1111/imr.12703
Alternate JournalImmunol. Rev.
PubMed ID30294971
PubMed Central IDPMC6195227
Grant ListR21 DK110262 / DK / NIDDK NIH HHS / United States
/ / Searle Scholars Program /
/ / Roberts Institute for Research in IBD /
/ / NIAID Mucosal Immunology Studies Team (MIST) /
/ / Crohn's and Colitis Foundation of America /
F32 AI134018 / AI / NIAID NIH HHS / United States
/ / Meyer Cancer Center Collaborative Research Initiative /
/ / Cancer Research Institute CLIP grant /
R01 AI123368 / AI / NIAID NIH HHS / United States
DP5 OD012116 / OD / NIH HHS / United States
U01AI095608 / / National Institutes of Health /
DP5OD012116 / / National Institutes of Health /
F32AI134018 / / National Institutes of Health /
R01AI123368 / / National Institutes of Health /
/ / Center for Advanced Digestive Care (CADC) /
/ / Weill Cornell Medicine Pre-Career Award /
U01 AI095608 / AI / NIAID NIH HHS / United States
/ / Burroughs Wellcome Fund /
R21DK110262 / / National Institutes of Health /
/ / American Asthma Foundation Scholar Award /