Submitted by jec3011 on February 24, 2020 - 4:26pm
| Title | MerTK Blockade Fuels Anti-tumor Immunity. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | J Blander, M |
| Journal | Immunity |
| Volume | 52 |
| Issue | 2 |
| Pagination | 212-214 |
| Date Published | 2020 Feb 18 |
| ISSN | 1097-4180 |
| Abstract | Phagocytosis of apoptotic cells via the receptor MerTK is important for immune tolerance. In this issue of Immunity, Zhou et al. report that blockade of MerTK-mediated phagocytosis mobilizes anti-tumor immunity through a mechanism that involves the transport of tumor-derived cGAMP into macrophages via the ATP-activated channel P2X7R. |
| DOI | 10.1016/j.immuni.2020.01.015 |
| Alternate Journal | Immunity |
| PubMed ID | 32075723 |