MerTK Blockade Fuels Anti-tumor Immunity.

TitleMerTK Blockade Fuels Anti-tumor Immunity.
Publication TypeJournal Article
Year of Publication2020
AuthorsJ Blander, M
JournalImmunity
Volume52
Issue2
Pagination212-214
Date Published2020 Feb 18
ISSN1097-4180
Abstract

Phagocytosis of apoptotic cells via the receptor MerTK is important for immune tolerance. In this issue of Immunity, Zhou et al. report that blockade of MerTK-mediated phagocytosis mobilizes anti-tumor immunity through a mechanism that involves the transport of tumor-derived cGAMP into macrophages via the ATP-activated channel P2X7R.

DOI10.1016/j.immuni.2020.01.015
Alternate JournalImmunity
PubMed ID32075723