Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis.

TitleInnate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis.
Publication TypeJournal Article
Year of Publication2016
AuthorsKlose, CSN, Artis, D
JournalNat Immunol
Volume17
Issue7
Pagination765-74
Date Published2016 Jun 21
ISSN1529-2916
Abstract

Research over the last 7 years has led to the formal identification of innate lymphoid cells (ILCs), increased the understanding of their tissue distribution and has established essential functions of ILCs in diverse physiological processes. These include resistance to pathogens, the regulation of autoimmune inflammation, tissue remodeling, cancer and metabolic homeostasis. Notably, many ILC functions appear to be regulated by mechanisms distinct from those of other innate and adaptive immune cells. In this Review, we focus on how group 2 ILC (ILC2) and group 3 ILC (ILC3) responses are regulated and how these cells interact with other immune and non-immune cells to mediate their functions. We highlight experimental evidence from mouse models and patient-based studies that have elucidated the effects of ILCs on the maintenance of tissue homeostasis and the consequences for health and disease.

DOI10.1038/ni.3489
Alternate JournalNat. Immunol.
PubMed ID27328006