The latest study from the Jill Roberts Institute, "CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi," was published on January 11 in Science. To read more, click here.  Dr. Gregory Sonnenberg wins inaugural award from the Society for Mucosal Immunology. To read more, click here.  The Kenneth Rainin Foundation awarded Dr. Iliyan Iliev and colleagues from Mount Sinai a $250,000 Synergy Award to examine the composition of the fungal community in babies born to mothers with inflammatory bowel disease. To read more, click here. Dr. Randy Longman received the Irma T. Hirschl Career Scientist Award and the New York Crohn’s Foundation Award.    

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Host-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases.

TitleHost-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases.
Publication TypeJournal Article
Year of Publication2017
AuthorsGrigg, JB, Sonnenberg, GF
JournalJ Immunol
Date Published2017 Jan 15

Recent advances in understanding how the mammalian immune system and intestinal microbiota functionally interact have yielded novel insights for human health and disease. Modern technologies to quantitatively measure specific members and functional characteristics of the microbiota in the gastrointestinal tract, along with fundamental and emerging concepts in the field of immunology, have revealed numerous ways in which host-microbiota interactions proceed beneficially, neutrally, or detrimentally for mammalian hosts. It is clear that the gut microbiota has a strong influence on the shape and quality of the immune system; correspondingly, the immune system guides the composition and localization of the microbiota. In the following review, we examine the evidence that these interactions encompass homeostasis and inflammation in the intestine and, in certain cases, extraintestinal tissues. Lastly, we discuss translational therapies stemming from research on host-microbiota interactions that could be used for the treatment of chronic inflammatory diseases.

Alternate JournalJ. Immunol.
PubMed ID28069751
PubMed Central IDPMC5228396
Grant ListDP5 OD012116 / OD / NIH HHS / United States
R01 AI123368 / AI / NIAID NIH HHS / United States
R21 DK110262 / DK / NIDDK NIH HHS / United States
U01 AI095608 / AI / NIAID NIH HHS / United States