Gut Mycobiota in Immunity and Inflammatory Disease.

TitleGut Mycobiota in Immunity and Inflammatory Disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsLi, XV, Leonardi, I, Iliev, ID
JournalImmunity
Volume50
Issue6
Pagination1365-1379
Date Published2019 Jun 18
ISSN1097-4180
Abstract

The mammalian intestine is colonized by a wealth of microorganisms-including bacteria, viruses, protozoa, and fungi-that are all integrated into a functional trans-kingdom community. Characterization of the composition of the fungal community-the mycobiota-has advanced further than the much-needed mechanistic studies. Recent findings have revealed roles for the gut mycobiota in the regulation of host immunity and in the development and progression of human diseases of inflammatory origin. We review these findings here while placing them in the context of the current understanding of the pathways and cellular networks that induce local and systemic immune responses to fungi in the gastrointestinal tract. We discuss gaps in knowledge and argue for the importance of considering bacteria-fungal interactions as we aim to define the roles of mycobiota in immune homeostasis and immune-associated pathologies.

DOI10.1016/j.immuni.2019.05.023
Alternate JournalImmunity
PubMed ID31216461
PubMed Central IDPMC6585451
Grant ListR01 DK113136 / DK / NIDDK NIH HHS / United States
R21 AI146957 / AI / NIAID NIH HHS / United States
R56 AI137157 / AI / NIAID NIH HHS / United States