The latest study from the Jill Roberts Institute, "CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi," was published on January 11 in Science. To read more, click here.  Dr. Gregory Sonnenberg wins inaugural award from the Society for Mucosal Immunology. To read more, click here.  The Kenneth Rainin Foundation awarded Dr. Iliyan Iliev and colleagues from Mount Sinai a $250,000 Synergy Award to examine the composition of the fungal community in babies born to mothers with inflammatory bowel disease. To read more, click here. Dr. Randy Longman received the Irma T. Hirschl Career Scientist Award and the New York Crohn’s Foundation Award.    

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Fungal dysbiosis: immunity and interactions at mucosal barriers.

TitleFungal dysbiosis: immunity and interactions at mucosal barriers.
Publication TypeJournal Article
Year of Publication2017
AuthorsIliev, ID, Leonardi, I
JournalNat Rev Immunol
Date Published2017 Oct
KeywordsAnimals, Dysbiosis, Fungi, Gastrointestinal Microbiome, Humans, Immunity, Mucosal, Skin, Symbiosis

Fungi and mammals share a co-evolutionary history and are involved in a complex web of interactions. Studies focused on commensal bacteria suggest that pathological changes in the microbiota, historically known as dysbiosis, are at the root of many inflammatory diseases of non-infectious origin. However, the importance of dysbiosis in the fungal community - the mycobiota - was only recently acknowledged to have a pathological role, as novel findings have suggested that mycobiota disruption can have detrimental effects on host immunity. Fungal dysbiosis and homeostasis are dynamic processes that are probably more common than actual fungal infections, and therefore constantly shape the immune response. In this Review, we summarize specific mycobiota patterns that are associated with fungal dysbiosis, and discuss how mucosal immunity has evolved to distinguish fungal infections from dysbiosis and how it responds to these different conditions. We propose that gut microbiota dysbiosis is a collective feature of complex interactions between prokaryotic and eukaryotic microbial communities that can affect immunity and that can influence health and disease.

Alternate JournalNat. Rev. Immunol.
PubMed ID28604735
PubMed Central IDPMC5724762
Grant ListK99 DK098310 / DK / NIDDK NIH HHS / United States
R00 DK098310 / DK / NIDDK NIH HHS / United States
R21 AI123819 / AI / NIAID NIH HHS / United States