Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.

TitleEmerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.
Publication TypeJournal Article
Year of Publication2015
AuthorsZaiss, DMW, Gause, WC, Osborne, LC, Artis, D
JournalImmunity
Volume42
Issue2
Pagination216-26
Date Published2015 Feb 17
ISSN1097-4180
KeywordsAnimals, EGF Family of Proteins, Helminthiasis, Humans, Immune Tolerance, Inflammation, Influenza, Human, Mice, Neoplasms, Orthomyxoviridae Infections, Receptor, Epidermal Growth Factor, Regeneration, Tumor Escape, Wound Healing
Abstract

<p>Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens, and infectious agents, and play critical roles in resistance and tolerance associated with infection, wound healing, tissue repair, and tumor development. Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2s), and a subset of tissue-resident regulatory CD4(+) T cells can express AREG. In this review, we discuss recent advances in our understanding of the AREG-EGF receptor pathway and its involvement in infection and inflammation and propose a model for the function of this pathway in the context of resistance and tissue tolerance.</p>

DOI10.1016/j.immuni.2015.01.020
Alternate JournalImmunity
PubMed ID25692699
Grant ListAI031678 / AI / NIAID NIH HHS / United States
AI061570 / AI / NIAID NIH HHS / United States
AI074878 / AI / NIAID NIH HHS / United States
AI095466 / AI / NIAID NIH HHS / United States
AI095608 / AI / NIAID NIH HHS / United States
AI097333 / AI / NIAID NIH HHS / United States
AI102942 / AI / NIAID NIH HHS / United States
AI106697 / AI / NIAID NIH HHS / United States
AI107588 / AI / NIAID NIH HHS / United States
MR/M011755/1 / / Medical Research Council / United Kingdom