Submitted by smf2001 on February 11, 2016 - 3:35pm
Title | The biology of innate lymphoid cells. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Artis, D, Spits, H |
Journal | Nature |
Volume | 517 |
Issue | 7534 |
Pagination | 293-301 |
Date Published | 2015 Jan 15 |
ISSN | 1476-4687 |
Keywords | Animals, Homeostasis, Humans, Immunity, Innate, Inflammation, Killer Cells, Natural, Lymphocytes, Transcription, Genetic |
Abstract | <p>The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.</p> |
DOI | 10.1038/nature14189 |
Alternate Journal | Nature |
PubMed ID | 25592534 |
Grant List | AI061570 / AI / NIAID NIH HHS / United States AI074878 / AI / NIAID NIH HHS / United States AI095466 / AI / NIAID NIH HHS / United States AI095608 / AI / NIAID NIH HHS / United States AI097333 / AI / NIAID NIH HHS / United States AI102942 / AI / NIAID NIH HHS / United States AI106697 / AI / NIAID NIH HHS / United States |