The biology of innate lymphoid cells.

TitleThe biology of innate lymphoid cells.
Publication TypeJournal Article
Year of Publication2015
AuthorsArtis, D, Spits, H
JournalNature
Volume517
Issue7534
Pagination293-301
Date Published2015 Jan 15
ISSN1476-4687
KeywordsAnimals, Homeostasis, Humans, Immunity, Innate, Inflammation, Killer Cells, Natural, Lymphocytes, Transcription, Genetic
Abstract

<p>The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.</p>

DOI10.1038/nature14189
Alternate JournalNature
PubMed ID25592534
Grant ListAI061570 / AI / NIAID NIH HHS / United States
AI074878 / AI / NIAID NIH HHS / United States
AI095466 / AI / NIAID NIH HHS / United States
AI095608 / AI / NIAID NIH HHS / United States
AI097333 / AI / NIAID NIH HHS / United States
AI102942 / AI / NIAID NIH HHS / United States
AI106697 / AI / NIAID NIH HHS / United States