Activation and Suppression of Group 3 Innate Lymphoid Cells in the Gut.

TitleActivation and Suppression of Group 3 Innate Lymphoid Cells in the Gut.
Publication TypeJournal Article
Year of Publication2020
AuthorsZhou, W, Sonnenberg, GF
JournalTrends Immunol
Volume41
Issue8
Pagination721-733
Date Published2020 08
ISSN1471-4981
Abstract

Group 3 innate lymphoid cells (ILC3s) have emerged as master regulators of intestinal health and tissue homeostasis in mammals. Through a diverse array of cytokines and cellular interactions, ILC3s crucially orchestrate lymphoid organogenesis, promote tissue protection or regeneration, facilitate antimicrobial responses, and directly regulate adaptive immunity. Further, translational studies have found that ILC3 responses are altered in the intestine of defined patient populations with chronic infectious, inflammatory, or metabolic diseases. Therefore, it is essential to broadly understand the signals that activate, suppress, or fine-tune ILC3s in the gut. Here, we discuss recent exciting advances in this field, integrate them into our current understanding of ILC3 biology, and highlight fundamental gaps in knowledge that require additional investigation.

DOI10.1016/j.it.2020.06.009
Alternate JournalTrends Immunol
PubMed ID32646594
PubMed Central IDPMC7395873
Grant ListR21 CA249274 / CA / NCI NIH HHS / United States
R01 AI145989 / AI / NIAID NIH HHS / United States
R01 AI123368 / AI / NIAID NIH HHS / United States
R01 AI143842 / AI / NIAID NIH HHS / United States
U01 AI095608 / AI / NIAID NIH HHS / United States