Dr. Chun-Jun Guo Receives NIH New Innovator Award. To read more, click here. The latest JRI studies: Published December 23 in Science, Dr. Chun-Jun Guo and his colleagues developed a new tool, a CRISPR-Cas-based genome editing system that allows genome editing of gut bacteria. To read more, click here. Published October 23 in Nature, the study reveals new cellular and molecular processes underlying communication between gut microbes and brain cells, described for the first time by scientists at Weill Cornell Medicine and Cornell’s Ithaca campus. To read more, click here.

The Jill Roberts Institute for Research in Inflammatory Bowel Disease

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Randy Longman, M.D., Ph.D.

Assistant Professor of Medicine

I am a gastroenterologist and mucosal immunologist focused on basic research to understand the causes and to develop new therapies for inflammatory bowel diseases (IBD).  Inflammatory bowel disease (IBD) affects over 2 million Americans.  While pharmacologic advances have improved the care of these patients, many still have refractory disease with significant morbidity.  IBD includes two distinct clinical phenotypes called Crohn’s disease and ulcerative colitis.  Genetic polymorphisms correlate with disease susceptibility, but they are rarely fully penetrant reflecting a central role for environmental triggers in disease pathogenesis.  While indeed certain luminal microbes may act as opportunistic pathogens causing infection and inflammation, we and others have shown that microbiota function as a double-edged sword to simultaneously suppress aberrant immune cell activation (homeostatic inhibition) and maintain homeostasis (homeostatic induction) at mucosal surfaces.  Thus, the major focus of our work is to define cellular and molecular regulation of innate intestinal barrier immunity and to harness the power of IBD-associated microbiota to develop novel diagnostic and therapeutic approaches to medically refractory IBD.

Education and Training

  • M.D., Weill Cornell Medical College 2007
  • Ph.D., The Rockefeller University 2006


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Grants awarded

Weill Cornell Medicine The Jill Roberts Institute for Research in Inflammatory Bowel Disease 413 E 69th Street, 7th Floor New York, NY 10021 Phone: (646) 962-6312