The Jill Roberts Institute for Research in Inflammatory Bowel Disease

The Jill Roberts Institute for IBD is part of a joint partnership that created Healing Hands: Pediatric GI Patients Describe Their Experience, culminating in an online art exhibition to raise awareness about pediatric gastroenterology-related illness and advocate for pediatric gastroenterology research. To see these stunning works in our online exhibition, please click here. The latest JRI studies: A new paper published in Nature on December 1 shows a set of immune cells called group 3 innate lymphoid cells (ILC3s) that normally protect against inflammation in the gastrointestinal tract may have the opposite effect in multiple sclerosis (MS). To read more, click here. A recent paper published in Nature Microbiology on November 22 finds that antibodies that are secreted in the gut help control the pathogenesis of Candida albicans in healthy individuals and that this protective mechanism may be disabled in people with Crohn’s disease. To read more, click here. Reported on October 1 in Gastroenterology, researchers sampled gut bacteria from healthy FMT donors and from FMT recipients with ulcerative colitis, identifying the bacterial strains whose transfer correlates with treatment effectiveness. To read more, click here.

 

Journal Covers 2018-April 2020

Featured JRI Covers from Science Immunology, October 2019; Immunity, April 14, 2020; Cell Host & Microbe, December 12, 2018 and May 13, 2020.

Svetlana working at the bench

A postdoctoral scientist working at the lab bench.

Chris Parkhurst cortical neuron cultured from the early postnatal mouse brain

A cortical neuron cultured from the early postnatal brain, stained for the neuron specific marker Tuj1 (green) along with excitatory synaptic marker GLUT1 (blue) and the inhibitory synaptic marker Gephyrin (red). Image courtesy of Drs. David Artis and Christopher Parkhurst

Mai at bench preparing for PCR

A lab technician processing tissue samples at the lab bench to run a polymerase chain reaction (PCR). It is a technique used to amplify a segment of DNA of interest by producing lots and lots of copies.

Chris Parkhurst Mouse meninges whole mount preparation stained

Meninges whole mount preparation stained for nuclei (DAPI), Tuj1 (green), or CD45 (red). Image courtesy of Drs. David Artis and Christopher Parkhurst

Nick and Samah working on experiment design at white board

Two lab members working on experiment design.

IL-33 in intestinal epithelial cells Artis lab

Immunostaining of the small intestine of a transgenic mouse expressing the cytokine interleukin 33
(IL-33; green) in the nuclei (blue) of intestinal epithelial cells (purple). Stromal cells stained red.
Interleukin-33 is a protein released from damaged or infected cells, initiating type 2 immune
responses. Image courtesy of Drs. Tanel Mahlakõiv and David Artis.

Immune Cells Heal the Intestine by Controlling Iron Sonnenberg Lab

Color-enhanced images of the large intestine from a mouse that has repaired following injury (left) and the large intestine from a mouse lacking hepcidin that was unable to repair (right). Image credit: Drs. Nicholas J. Bessman and Gregory Sonnenberg.

Artistic rendering of a tumor growing within a colon

Artistic rendering of a tumor growing within a colon, resulting in local alterations of resident microbiota. Artist/Image Source: Sarah Field Sonnenberg

Mucus Inflammed Lung Tissue Artis

Mucus production (red) in the lung under inflammatory conditions. Picture courtesy of Drs. David Artis and Saya Moriyama.

The Jill Roberts Institute for Research in Inflammatory Bowel Disease

A Message From the Director

We welcome you to the Jill Roberts Institute for Research in Inflammatory Bowel Disease (IBD). The mission of the Institute is to establish a multidisciplinary center of excellence that will accelerate new cutting edge scientific discoveries at both the basic and translational level, which collectively will advance innovative preventative and therapeutic approaches for IBD and other related inflammatory diseases. Our goal is to propel a paradigm shift in how we approach the research, treatment, prevention and cure of chronic inflammatory diseases by establishing interactive and successful collaborations between basic researchers, clinicians, pathologists, surgeons and bioinformaticians.

 

Please explore the website: meet our faculty, staff and trainees, learn more about our research programs and teaching efforts, and read about our recent publications and press releases. 

 

Please contact us if you have any questions.

 

Sincerely,

 

David Artis

Michael Kors Professor of Immunology

Director, Jill Roberts Institute

Director, Friedman Center for Nutrition and Inflammation

Weill Cornell Medicine

 

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