The latest study from the Jill Roberts Institute, "The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation," was published on September 6 in Nature. To read more, click here.     Dr. Gregory Sonnenberg wins inaugural award from the Society for Mucosal Immunology. To read more, click here.  The Kenneth Rainin Foundation awarded Dr. Iliyan Iliev and colleagues from Mount Sinai a $250,000 Synergy Award to examine the composition of the fungal community in babies born to mothers with inflammatory bowel disease. To read more, click here. Dr. Randy Longman received the Irma T. Hirschl Career Scientist Award and the New York Crohn’s Foundation Award.    

The Jill Roberts Institute for Research in Inflammatory Bowel Disease

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Gregory Sonnenberg, Ph.D.

Assistant Professor of Microbiology and Immunology in Medicine

The focus and long-term research goals of the Sonnenberg Laboratory are to interrogate the mechanisms that maintain a state of health in the human gastrointestinal tract.  This is a considerable challenge given the enormous surface area of this organ in which a single layer of intestinal epithelial cells segregates an estimated 100 trillion commensal bacteria from a significant portion of our bodies total immune system.  While interactions between mammalian hosts and commensal bacteria are normally beneficial, it is becoming increasingly clear the dysregulated interactions can result in chronic inflammation.  Further, emerging studies in patient populations indicate that abnormal host immune responses to commensal bacteria are causally-linked to the pathogenesis and progression of numerous chronic infectious, inflammatory and metabolic diseases, including inflammatory bowel disease (IBD), HIV/AIDS, viral hepatitis, cardiovascular disease, obesity, diabetes and cancer.  Ongoing research in the Sonnenberg Laboratory aims to (1) interrogate the pathways that regulate normally beneficial host interactions with commensal bacteria, (2) determine how these pathways become disrupted in chronic human diseases, and (3) identify novel therapeutic targets to prevent or limit dysregulated host-commensal bacteria relationships in human disease.

 

Education and Training

  • Ph.D., University of Pennsylvania 2011
  • B.S., State University of New York at Buffalo 2007

 

View Recent Publications

 

Grants awarded

Weill Cornell Medicine The Jill Roberts Institute for Research in Inflammatory Bowel Disease 413 E 69th Street, 7th Floor New York, NY 10021 Phone: (646) 962-6312