The Jill Roberts Institute for Research in Inflammatory Bowel Disease

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Research and Press Releases

Research Uncovers Bacteria Linking Crohn’s Disease to Arthritis

Patients with Crohn’s disease, a type of inflammatory bowel disease (IBD) that causes abdominal pain and diarrhea, can also experience joint pain. In Crohn’s disease, which affects about 800,000 Americans, the immune system can attack not only the bowels, but the musculoskeletal system as well, leading to spondyloarthritis, a painful condition that affects the spine and joints. Now new research, published Feb. 8 in Science Translational Medicine, helps explain the connection between these seemingly unrelated symptoms, and could help physicians identify Crohn’s disease patients who are more likely to develop spondyloarthritis, enabling them to prescribe more effective therapies for both conditions.

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Cell Death in Gut Implicated in IBD

The natural lifecycle of cells that line the intestine is critical to preserving stable conditions in the gut, according to new research led by a Weill Cornell Medicine investigator. The findings may lead to the development of new therapies to alleviate inflammatory bowel disease (IBD) and other chronic inflammatory illnesses.

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Kenneth Rainin Foundation Awards $750,000 for Collaborative Inflammatory Bowel Disease Research Projects

OAKLAND, Calif., Feb. 14, 2017 /PRNewswire-USNewswire/ -- The Kenneth Rainin Foundation announced today that it has awarded $750,000 for Inflammatory Bowel Disease (IBD) research through its Synergy Award program. The Rainin Foundation funds scientific projects that have the potential to yield transformative discoveries and major insights into predicting and preventing IBD.

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Investigator Wins Award to Continue Study of Fungi in Inflammatory Bowel Disease

Dr. Iliyan Iliev, an assistant professor of immunology in medicine at Weill Cornell Medicine, has been awarded a one-year, $100,000 grant from the Kenneth Rainin Foundation to study the behavior of fungi in the immune system when patients with inflammatory bowel disease are administered a form of immunotherapy.  

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NYC IBD Research Day 2016

New York City IBD Research Day, on Nov 7, 2016, was a success.  Over 200 attendees enjoyed presentations on a variety of research presented by a multitude of lecturers from around the globe. The symposium was a one day event hosted by the Jill Roberts Institute at the Weill Cornell Medicine Belfer Research Building, in collaboration with the Immunology Institute of the Icahn School of Medicine at Mount Sinai, and the Center for Basic and Translational Research on Disorders of the Digestive System at The Rockefeller University. Dr. Richard Blumberg of Harvard Medical School was presented with the Lloyd F. Mayer, MD award.


The Fungus Among Us

NEW YORK (July 25, 2016) - By now, most of us have made peace with the fact that we are host to a complicated extended family of bacteria whose trillion-plus members give us vitamins, help us digest food, protect us from pathogens, and only rarely turn virulent on us. But what about the fungus among us?

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Disruption of Intestinal Fungi Leads to Increased Severity of Inflammatory Disease

Fungi that live in a healthy gut may be as important for good health as beneficial intestinal bacteria, according to new research conducted at Weill Cornell Medicine.

Scientists have known for quite some time that the so-called "good" gut bacteria in the intestines, known as commensal bacteria, are a key component of a healthy body. These bacteria are critical for proper digestive and immune system function. Recent discoveries, however, have indicated that other microbes, such as fungi and viruses, may also play a part in how the body handles inflammation.

Continue reading at: http://weill.cornell.edu/news/news/2016/06/disruption-of-intestinal-fung...


An Off-Switch for Allergy: Starving the Immune System Prevents Allergic Inflammation in the Lung

NEW YORK (April 4, 2016) — Starving immune cells of key nutrients stymies their ability to launch an allergic response, according to new research from a multi-institutional collaboration led by Weill Cornell Medicine investigators. The findings illuminate how nutrients help drive tissue inflammation caused by the immune system — an insight that could lead to new treatments for a wide range of inflammatory conditions from hay fever and food allergies to asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF).

Continue to read at: http://weill.cornell.edu/news/news/2016/04/an-off-switch-for-allergy-sta...


Bacteria in Immune Cells May Protect Against Chronic Inflammation

NEW YORK (March 15, 2016) — A population of bacteria inhabits human and mouse immune cells and appears to protect the body from inflammation and illness, Weill Cornell Medicine scientists discovered in a new study. The findings challenge conventional wisdom about the relationship between bacteria and the human body — and about how the microbes influence health and disease. The study, published March 15 in Immunity, focused on "good" or "commensal" bacteria that live in the human intestine and are essential for digestion and proper immune function.

Continue reading at: http://weill.cornell.edu/news/news/2016/03/bacteria-in-immune-cells-may-...


Innovative Therapeutic Approach Shows Promise in Treating Inflammatory Bowel Disease

NEW YORK (February 16, 2016) — An investigative therapy given to mice blocks the overactive immune responses that are a hallmark of inflammatory bowel disease without impairing the body's ability to fight infection, an international research team led by Weill Cornell Medicine investigators finds in a new study. The preclinical discovery may lead to more effective treatment strategies for IBD.

Continue to read at: http://weill.cornell.edu/news/news/2016/02/hed-innovative-therapeutic-ap...


Restoring "Gut Health" in Patients with Inflammatory Bowel Disease May Be a Matter of Pushing Cells to Repair Our Tissues

NEW YORK (August 04, 2015) — New insight into how the intestines repair themselves after daily attacks from microbes and other environmental triggers could lead to innovative approaches to treating inflammatory bowel disease, according to new research by Weill Cornell Medical College investigators. The findings, published Aug. 4 in PNAS, reveal a mechanism that allows the single layer of cells that line the inside of the intestines, called the gut epithelium, to signal the immune system to repair tissue damage caused by the daily onslaught of microbes and other environmental factors that the body encounters. Because a defect in that repair system underlies Crohn's disease and ulcerative colitis, the two primary forms of IBD, restoring tissue-protective repair mechanisms could reduce the diseases' hallmarks, chronic inflammation and tissue damage.

Continue reading at: http://weill.cornell.edu/news/news/2015/08/restoring-gut-health-in-patie...


Weill Cornell Investigators Discover a New Pathway that Prevents Chronic Inflammation in the Gut

New York (April 23, 2015) — An international research team led by Weill Cornell Medical College investigators has discovered an answer to why the human immune system ignores roughly 100 trillion beneficial bacteria that populate the gastrointestinal tract. The findings, published April 23 in the journal Science, advance investigators' understanding of how humans maintain a healthy gastrointestinal tract, and may provoke new ways to treat inflammatory bowel disease — including Crohn's disease and ulcerative colitis — whose origins have been mysterious and treatment difficult.

Continue reading at: http://weill.cornell.edu/news/pr/2015/04/weill-cornell-investigators-dis...


Immune Cells in "White" Body Fat Limit Obesity, Researchers Say

In the Dec. 22 issue of Nature, a research team, led by investigators at Weill Cornell Medical College, has found that an immune cell type appears to help burn fat and prevent the development of obesity. The findings suggest new ways of possibly preventing or treating obesity and obesity-related diseases in humans, says the study's senior investigator, Dr. David Artis, an immunologist who leads the Jill Roberts Institute for Research in Inflammatory Bowel Disease at Weill Cornell.

Continue reading at: http://weill.cornell.edu/news/news/2014/12/immune-cells-in-white-body-fa...


JRI Investigators Featured in Weill Cornell Medicine: Inside Medicine


Jill Roberts Institute for Research in Inflammatory Bowel Disease Leads the Field

NEW YORK (April 18, 2016) — A string of high-profile research studies underscores the early successes of the Jill Roberts Institute for Research in Inflammatory Bowel Disease, where scientists are assiduously investigating the root causes of the disease. Now, with the official opening of its permanent laboratories, the Weill Cornell Medicine institute is poised to lead the way in advancing research to improve patient care. Established nearly two years ago with a generous gift to Weill Cornell Medicine from longtime benefactor Jill Roberts, the institute uses a multidisciplinary approach to drive and then translate discoveries into new preventative and treatment strategies for IBD, a group of chronic inflammatory conditions of the intestine that affects an estimated 3.5 million people worldwide.

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New Jill Roberts Institute for Research in Inflammatory Bowel Disease Established at Weill Cornell Medical College

NEW YORK — Weill Cornell Medical College announced today that through the generosity of longstanding benefactor Jill Roberts and the Jill Roberts Charitable Foundation it is establishing the Jill Roberts Institute for Research in Inflammatory Bowel Disease. Dr. David Artis, one of the world's leading immunologists, was recruited from the University of Pennsylvania School of Medicine to direct the institute, which is dedicated to understanding the molecular underpinnings of inflammatory bowel disease with the goal of translating basic research breakthroughs into the most advanced therapies for patients.

Continue reading at: http://weill.cornell.edu/news/pr/2014/06/new-jill-roberts-institute-for-research-in-inflammatory-bowel-disease-established-at-weill-cornell-m.html


Weill Cornell Medicine The Jill Roberts Institute for Research in Inflammatory Bowel Disease 413 E 69th Street, 7th Floor New York, NY 10021 Phone: (646) 962-6312