The latest study from the Jill Roberts Institute, "The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation," was published on September 6 in Nature. To read more, click here.     Dr. Gregory Sonnenberg wins inaugural award from the Society for Mucosal Immunology. To read more, click here.  The Kenneth Rainin Foundation awarded Dr. Iliyan Iliev and colleagues from Mount Sinai a $250,000 Synergy Award to examine the composition of the fungal community in babies born to mothers with inflammatory bowel disease. To read more, click here. Dr. Randy Longman received the Irma T. Hirschl Career Scientist Award and the New York Crohn’s Foundation Award.    

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Vita-PAMPs: signatures of microbial viability.

TitleVita-PAMPs: signatures of microbial viability.
Publication TypeJournal Article
Year of Publication2013
AuthorsMourao-Sa, D, Roy, S, J Blander, M
JournalAdv Exp Med Biol
Volume785
Pagination1-8
Date Published2013
ISSN0065-2598
KeywordsBacteria, Bacterial Infections, Humans, Immunity, Innate, Microbial Viability, Receptors, Pattern Recognition, RNA, Bacterial, RNA, Messenger, Signal Transduction, Virulence Factors
Abstract

Can the innate immune system detect and respond to microbial viability? Using bacteria as a model, we found that indeed the very essence of microbial infectivity, viability itself, can be detected, and notably, in the absence of the activity of virulence factors. The microbial molecule that serves as the signature of viability is bacterial messenger RNA (mRNA), common to all bacteria, and without which bacteria cannot survive. Prokaryotic mRNAs also differ from eukaryotic mRNAs in several ways, and as such, these features all fulfill the criteria, and more, for a pathogen-associated molecular pattern (PAMP) as originally proposed by Charles Janeway. Because these mRNAs are lost from dead bacteria, they belong to a special class of PAMPs, which we call vita-PAMPs. Here we discuss the possible receptors and pathways involved in the detection of bacterial mRNAs, and thus microbial viability. We also consider examples of vita-PAMPs other than bacterial mRNA.

DOI10.1007/978-1-4614-6217-0_1
Alternate JournalAdv. Exp. Med. Biol.
PubMed ID23456832