The latest study from the Jill Roberts Institute, "The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation," was published on September 6 in Nature. To read more, click here.     Dr. Gregory Sonnenberg wins inaugural award from the Society for Mucosal Immunology. To read more, click here.  The Kenneth Rainin Foundation awarded Dr. Iliyan Iliev and colleagues from Mount Sinai a $250,000 Synergy Award to examine the composition of the fungal community in babies born to mothers with inflammatory bowel disease. To read more, click here. Dr. Randy Longman received the Irma T. Hirschl Career Scientist Award and the New York Crohn’s Foundation Award.    

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Regulation of phagosome maturation by signals from toll-like receptors.

TitleRegulation of phagosome maturation by signals from toll-like receptors.
Publication TypeJournal Article
Year of Publication2004
AuthorsJ Blander, M, Medzhitov, R
JournalScience
Volume304
Issue5673
Pagination1014-8
Date Published2004 May 14
ISSN1095-9203
KeywordsAdaptor Proteins, Signal Transducing, Animals, Antigens, Differentiation, Apoptosis, Bacteria, Enzyme Activation, Enzyme Inhibitors, Escherichia coli, Lysosomes, Macrophages, Membrane Glycoproteins, Mice, Microscopy, Immunoelectron, Mitogen-Activated Protein Kinases, Myeloid Differentiation Factor 88, p38 Mitogen-Activated Protein Kinases, Phagocytosis, Phagosomes, Receptors, Cell Surface, Receptors, Immunologic, Recombinant Proteins, Salmonella typhimurium, Signal Transduction, Staphylococcus aureus, Toll-Like Receptors
Abstract

In higher metazoans, phagocytosis is essential in host defense against microbial pathogens and in clearance of apoptotic cells. Both microbial and apoptotic cells are delivered on a common route from phagosomes to lysosomes for degradation. Here, we found that activation of the Toll-like receptor (TLR) signaling pathway by bacteria, but not apoptotic cells, regulated phagocytosis at multiple steps including internalization and phagosome maturation. Phagocytosis of bacteria was impaired in the absence of TLR signaling. Two modes of phagosome maturation were observed, constitutive and inducible; their differential engagement depended on the ability of the cargo to trigger TLR signaling.

DOI10.1126/science.1096158
Alternate JournalScience
PubMed ID15143282
Grant ListAI46688 / AI / NIAID NIH HHS / United States