Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

TitleIntestinal epithelial cells: regulators of barrier function and immune homeostasis.
Publication TypeJournal Article
Year of Publication2014
AuthorsPeterson, LW, Artis, D
JournalNat Rev Immunol
Volume14
Issue3
Pagination141-53
Date Published2014 Mar
ISSN1474-1741
KeywordsAdaptive Immunity, Animals, Antigen-Presenting Cells, Epithelial Cells, Homeostasis, Host-Pathogen Interactions, Humans, Immunity, Innate, Intestinal Mucosa, Intestine, Large, Intestine, Small, Lymphocytes, Mice, Signal Transduction, Symbiosis
Abstract

<p>The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host-microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host-commensal microbial relationships and immune cell homeostasis in the intestine.</p>

DOI10.1038/nri3608
Alternate JournalNat. Rev. Immunol.
PubMed ID24566914
Grant ListAI061570 / AI / NIAID NIH HHS / United States
AI074878 / AI / NIAID NIH HHS / United States
AI087990 / AI / NIAID NIH HHS / United States
AI095466 / AI / NIAID NIH HHS / United States
AI095608 / AI / NIAID NIH HHS / United States
AI097333 / AI / NIAID NIH HHS / United States
AI102942 / AI / NIAID NIH HHS / United States
AI106697 / AI / NIAID NIH HHS / United States
T32AI00744 / AI / NIAID NIH HHS / United States