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Immunity against fungi.

TitleImmunity against fungi.
Publication TypeJournal Article
Year of Publication2017
AuthorsLionakis, MS, Iliev, ID, Hohl, TM
JournalJCI Insight
Volume2
Issue11
Date Published2017 Jun 02
ISSN2379-3708
Abstract

Pathogenic fungi cause a wide range of syndromes in immune-competent and immune-compromised individuals, with life-threatening disease primarily seen in humans with HIV/AIDS and in patients receiving immunosuppressive therapies for cancer, autoimmunity, and end-organ failure. The discovery that specific primary immune deficiencies manifest with fungal infections and the development of animal models of mucosal and invasive mycoses have facilitated insight into fungus-specific recognition, signaling, effector pathways, and adaptive immune responses. Progress in deciphering the molecular and cellular basis of immunity against fungi is guiding preclinical studies into vaccine and immune reconstitution strategies for vulnerable patient groups. Furthermore, recent work has begun to address the role of endogenous fungal communities in human health and disease. In this review, we summarize a contemporary understanding of protective immunity against fungi.

DOI10.1172/jci.insight.93156
Alternate JournalJCI Insight
PubMed ID28570272