Group 3 innate lymphoid cells: regulating host-commensal bacteria interactions in inflammation and cancer.

TitleGroup 3 innate lymphoid cells: regulating host-commensal bacteria interactions in inflammation and cancer.
Publication TypeJournal Article
Year of Publication2016
AuthorsGoc, J, Hepworth, MR, Sonnenberg, GF
JournalInt Immunol
Volume28
Issue1
Pagination43-52
Date Published2016 Jan
ISSN1460-2377
Abstract

<p>A delicate balance exists between the mammalian immune system and normally beneficial commensal bacteria that colonize the gastrointestinal tract, which is necessary to maintain tissue homeostasis. Dysregulation of these interactions between the host and commensal bacteria is causally associated with chronic inflammation and the development of cancer. In contrast, recent reports have highlighted that commensal bacteria also play an essential role in promoting anti-tumor immune responses in several contexts, highlighting a paradox whereby interactions between the host and commensal bacteria can influence both pro- and anti-tumor immunity. Given the critical roles for group 3 innate lymphoid cells (ILC3s) in regulating inflammation, tissue repair and host-microbe interactions in the intestine, here we discuss new evidence that ILC3s may profoundly influence the development, progression and control of tumors. In this review, we provide an overview of recent advances in understanding the impact of commensal bacteria on tumorigenesis, discuss recent findings identifying ILC3s as critical regulators of host-microbe interactions and highlight the emerging role of this immune cell population in cancer and their potential implication as a therapeutic target.</p>

DOI10.1093/intimm/dxv056
Alternate JournalInt. Immunol.
PubMed ID26451009